A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.
Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.
Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.
A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.
A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.
Élet
Kivételes szerencsével léphettek be a 90-es évek közepe után született fiatalok a munkaerőpiacra
A gazdasági fellendülés időszakában pályára lépő fiatalok viszonylag könnyen találtak munkát jó fizetés mellett, kérdés, hogy ez miként hat a motivációjukra.
A kereslet visszafogásával érdemes csökkenteni az üzemanyagárakat
A kormány olcsóbb üzemanyagot szeretne, ám az élhető jövőt az szolgálná, ha ez azért valósulna meg, mert kevesebb benzinre és gázolajra van szükség.
Melyik paradicsom környezetbarátabb, a kiskertből szedett vagy a boltban vett?
Egy amerikai kutatás arra hívja fel a figyelmet, hogy a kérdésre nem is olyan egyértelmű a válasz.
Fontos
Kifulladni látszik a magyar államadósság-ráta csökkenése
Nemcsak rövid, hanem középtávon is magasan ragadhat az adósságráta, ami a gazdasági felzárkózási folyamatunkat is megnehezítheti.
Az új otthonfelújítási program átrendezheti a lakáshitelek piacát
A támogatás révén több tízmilliárd forint felújítási hitel jut majd a piacra, amelyhez várhatóan jelentős mennyiségű piaci feltételű kölcsön is társul majd.
Romba dőlnek az orosz remények Ukrajnában?
Jelenleg szinte minden harctéri körülmény az oroszoknak kedvez, az eddig elért eredményeik mégis szerények, miközben az ukránok lőszerhiánya hamarosan enyhül.
