Hírlevél feliratkozás
Torontáli Zoltán
2020. április 13. 10:52 Élet

Csak 12 molekula megfelelő sorrendben, és kész a világjárvány

A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.

Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.

Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.

A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.

A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.

Kapcsolódó cikkKapcsolódó cikkAz új világban a szabadságot jelentheti, ha valaki felgyógyult a koronavírusbólA gazdasága újraindítását tervező Olaszországban a tervek szerint azok mehetnek először munkába, és egyáltalán a szabadba, akik immunisak lehetnek a betegségre.

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