Hírlevél feliratkozás
Torontáli Zoltán
2020. április 13. 10:52 Élet

Csak 12 molekula megfelelő sorrendben, és kész a világjárvány

A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.

Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.

Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.

A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.

A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.

Kapcsolódó cikkKapcsolódó cikkAz új világban a szabadságot jelentheti, ha valaki felgyógyult a koronavírusbólA gazdasága újraindítását tervező Olaszországban a tervek szerint azok mehetnek először munkába, és egyáltalán a szabadba, akik immunisak lehetnek a betegségre.

Élet fehérje koronavírus molekula RNS sars tüske Olvasson tovább a kategóriában

Élet

Hajdu Miklós
2020. október 22. 12:17 Élet, Vállalat

Sokkal könnyebb olyan munkahelyre bejutni, ahol már dolgozik egy évfolyam- vagy szaktárs

Az egyetemisták nagyon jól segítik egymást a pályakezdésnél.

Torontáli Zoltán
2020. október 21. 13:47 Élet

A magyar fiatalok gyors ütemben közelítenek Nyugat-Európához

A magyar fiatalok gondolkodása a tipikus élethelyzetekről már csak körülbelül 12 éves csúszásban van Nyugat-Európához képest.

Stubnya Bence
2020. október 20. 16:43 Adat, Élet

A természeti erőforrások felélése árán nőtt a magyar gazdaság

Európa-bajnokok voltunk az erőforrások felhasználásában, miközben lebetonoztuk az országot a régiós átlagnál alacsonyabb gazdasági növekedésért cserébe.

Fontos

Kasnyik Márton
2020. október 25. 16:09 Adat

Többen élnek rosszabbul a járvány miatt, mint azt az adatokból elsőre gondolnánk

Első ránézésre úgy tűnhet, mintha ugyanannyian dolgoznának, mint a járvány előtti időben. De a változatlan számok mögött rosszabb minőségű munkahelyek vannak.

Fabók Bálint
2020. október 24. 17:09 Adat

Aggódunk a környezetért, csak fizetni ne kelljen érte

A klímaváltozás nincs az ország legfontosabb problémái között a magyarok többsége szerint, és kevesebben fizetnék meg a környezetvédelem árát, mint a 90-es években.

Bucsky Péter
2020. október 23. 07:06 Közélet

Kevesebb a hajléktalan, de egyre reménytelenebb a helyzetük

Az utóbbi évek gazdasági fellendülése során viszonylag sokan törtek ki a hajléktalanságból, a hátramaradók viszont egyre idősebbek és rosszabbul képzettek.