A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.
Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.
Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.
A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.
A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.
Élet
Meglepő városokban kell keresni a leggyorsabban dráguló lakótelepi lakásokat
Az abszolút listán Pest és Debrecen kiszorította Győrt és Sopront, de a leggyorsabb áremelkedés Komlón, Várpalotán, Miskolcon és Szegeden ment végbe.
Feles reggelire, cigi helyett Xanax, ebben a közegben indul kirakatháború a drogok ellen
Nem várható kedvező változás a kábítószer-ellenes felbuzdulástól, az egymilliárdos kocsmaprogramnak pedig nagyon rossz az üzenete szakemberek szerint.
Temetik az otthoni munkát, de éppen most alakul ki a mindenki számára hasznos formája
Szigorításról szólnak a hírek, pedig stabilizálódik a távmunka szerepe, és egyre inkább látszik, hogy hány irodai nappal kerülhetők el a hátrányai.
Fontos
Olyasmiben látott értéket, amiben más nem, erre alapozva válna globális céggé a magyar Datapao
A magyar adatelemző cég az egyike az ezer leggyorsabban növekvő európai cégnek a Financial Times szerint. De hogyan jutottak ide?
Ezért nem tud ma beszállni az árversenybe a sarki élelmiszerbolt
Az árrésstop minden korábbinál jobban megmutatta, milyen hatalmas előnyben vannak a nagy boltláncok a beszerzések terén a kisboltokhoz képest.
Európában a klímavédelem nyírta ki az olcsó kisautókat, Amerikában Trump vámjai fogják
Az áremelkedés miatt jellemzően az olcsóbb és kisebb típusok tűnhetnek el az amerikai autópiacról. Ilyeneket már Európában is egyre nehezebb találni.
