A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.
Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.
Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.
A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.
A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.
Élet
Meglepő városokban kell keresni a leggyorsabban dráguló lakótelepi lakásokat
Az abszolút listán Pest és Debrecen kiszorította Győrt és Sopront, de a leggyorsabb áremelkedés Komlón, Várpalotán, Miskolcon és Szegeden ment végbe.
Feles reggelire, cigi helyett Xanax, ebben a közegben indul kirakatháború a drogok ellen
Nem várható kedvező változás a kábítószer-ellenes felbuzdulástól, az egymilliárdos kocsmaprogramnak pedig nagyon rossz az üzenete szakemberek szerint.
Temetik az otthoni munkát, de éppen most alakul ki a mindenki számára hasznos formája
Szigorításról szólnak a hírek, pedig stabilizálódik a távmunka szerepe, és egyre inkább látszik, hogy hány irodai nappal kerülhetők el a hátrányai.
Fontos
Fosszilis reneszánszot hozhat az USA-ban, hogy a globális háború ijesztőbb lett a felmelegedésnél
Az új amerikai kormányzat úgy ítéli meg, az újraiparosítás fontosabb a klímavédelemnél. Trump céljai világosak, de semmi sem garantálja, hogy azok teljesülnek is.
Újra azzal úszta meg a sokmilliárdos büntetést a Mercedes, hogy feldobta kartelltársait
Olcsóbban akarták letudni a roncsautókkal kapcsolatos kötelezettségeiket a gyártók, de lebuktak, mert a Mercedes kibeszélt a kartellből – nem először.
Olyasmiben látott értéket, amiben más nem, erre alapozva válna globális céggé a magyar Datapao
A magyar adatelemző cég az egyike az ezer leggyorsabban növekvő európai cégnek a Financial Times szerint. De hogyan jutottak ide?
