A következő bekezdésnek a végére raktunk egy csillagot, amelyre kattintva egy három sorból, de majdnem 30 ezer karakterből álló gigantikus jegyzet nyílik meg. Nem várjuk, hogy ezt a jegyzetet a szó hétköznapi értelmében bárki elolvassa, mert nem szöveg. Ez csak egy olyan betűsorozat, amely végig négy elemet variál (a, c, g és u). Mind a négy betű egy bizonyos molekulát jelöl, és ha ezek ebben a megadott sorrendben kapcsolódnak egymáshoz, akkor a SARS-CoV-2 vírus RNS-ét, azaz örökítő anyagát alkotják.
Annak, aki hajlandó megnyitni ezt a szekvenciát, középre beletettünk egy törést: 12 karaktert kiemeltünk a 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Ez a 12 molekula a koronavírus egyik, minket nagyon-nagyon rosszul érintő betoldása. Ha ez a 12 molekula nem lenne benne ebben a hosszú polimerben, akkor a vírus felületén lévő tüskeszerű fehérjék nem tudnának ilyen kiválóan kapcsolódni az emberi sejtek falán lévő egyik receptorhoz, és ezért nem tudnának ilyen könnyen bejutni a sejtjeinkbe, azaz nem tudnának ilyen könnyen megfertőzni minket. A 30 ezer tagból álló RNS-ben mindez csak 0,04 százalékos módosítás.
Általános iskolai tanulmányainkból is emlékezhetünk rá, hogy a vírus nem élőlény, csak örökítő anyaga van, vagyis ahhoz, hogy szaporodjon, gazdasejtre van szüksége. Be kell jutnia a sejtjeinkbe, és a SARS-CoV-2 pont ennek a jelentéktelennek tűnő módosításnak köszönheti, hogy ezt sokkal hatékonyabban el tudja érni, mint az elődei.
A 2013-as SARS-járvány koronavírusa (SARS-CoV) hasonló volt, de mégsem ilyen hatékony. Az RNS-ben lévő molekulák sorrendje ugyanis nem más, mint kódok sorozata, amelyek különböző fehérjék legyártására adnak útmutatást. A SARS-CoV-2 újítása pedig pont azért ilyen hatékony, mert az RNS-e a koronavírusokra annyira jellemző, névadó tüskefehérjének egy olyan változatát állítja elő, amelynek alakja jobban illeszkedik az emberi sejt receptorának külsejéhez. Márpedig ha jobban illeszkedik, akkor erősebben, stabilabban tud kötődni hozzá.
A koronavírus-járvány talán minden eddiginél szélesebb körben teszi érthetővé azt, hogy a molekuláris biológia milyen magas fejlettségi szintre jutott, hogy az ember még a molekulák szintjén is milyen alaposan ismeri a természet működését, ám egy 12 molekulás beszúrás ennek ellenére is milyen kiszolgáltatottá tehet minket.
Élet
Alig érezné meg a gazdaság, ha december 24. piros betűs ünnep lenne
Az első évben körülbelül az egy napra eső GDP 20 százaléka esne ki, utána talán annyi sem, vagyis a lépésnek csekély gazdasági következménye lenne.
Szentkirályi Balázs-díjat alapít a G7
A G7 szerkesztősége, volt munkatársai díjat alapítanak a tavaly elhunyt Szentkirályi Balázs emlékére, aki a G7 2017-es alapítástól súlyos betegségéig a gazdasági portál vezérigazgatója, szerkesztője volt.
Milyen esélyekkel indul egy elhagyott csecsemő a magánkórházban születetthez képest?
Szerető családban eltűnhetnek a kezdeti viszontagságok következményei, de fontos, hogy minél kevesebb időt töltsenek átmeneti körülmények között.
Fontos
Éledezik az európai autópiac, de több ezer ember állását ez már nem menti meg
Az e-autók iránti kereslet továbbra is hanyatlik, de összességében kicsit erősödött az uniós autópiac októberben. A Volkswagennél és a Fordnál így is leépítések jönnek.
Fogy a levegő a jövő évi magyar gazdasági növekedés körül
1,8 és 2,2 százalékos növekedési előrejelzés is megjelent az elmúlt egy hétben, aligha lesz így ebből uniós szinten is kiemelkedő gazdasági teljesítmény.
Újabb nagy ingatlant vett a Balatonnál a csopakiakkal hadakozó kormányközeli üzletember
Egyetlen cég tett ajánlatot azon az árverésen, amelyet a nemzeti vagyonkezelő a csopaki honvédségi üdülő értékesítésére írt ki. A vevőt már ismerik a helyiek.
